Suojun Zhang, Feng Wan, Lin Han, Fei Ye, Dongsheng Guo and Ting Lei Pages 70 - 77 ( 8 )
Glioblastoma, a highly lethal brain tumor, features extensive heterogeneity at the cellular and molecular levels. The discovery of glioma stem cells (GSCs) supports a new paradigm in tumor biology and therapeutic targeting. GSCs contribute to the cellular origin of primary gliomas and the recurrence of malignant gliomas after traditional treatments. A growing body of evidence suggests that GSCs, just as the bulk tumor cells, are heterogeneous with phenotypic and genetic complexity. Heterogeneous GSCs may add to glioblastoma heterogeneity and impact response to current therapies. A better understanding of GSC heterogeneity is required to facilitate the design of more effective therapies against this highly malignant brain tumor.
Glioblastoma, glioma stem cells, heterogeneity.
Department of Neurosurgery and Chinese-German Lab of Molecular Neurooncology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Jiefang Avenue 1095#, Wuhan 430030, PR China.