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1,3,5-Triazine Analogs: A Potent Anticancer Scaffold

Author(s):

Rajeev Kumar*, Neeraj Kumar, Ram Kumar Roy and Anita Singh   Pages 1 - 20 ( 20 )

Abstract:


Background: This review presents the exhaustive exploration of 1,3,5-triazine scaffold for the development of analogs of anticancer drugs, over the last century. In the recent years, striazine moiety has been one of the most studied moiety, showing broad-spectrum pharmacological activities such as antibacterial, antifungal, analgesic, anti-HIV, antileishmanial, antitrypanosomal, antimalarial and antiviral. Nowadays, many boffins are have become interested in the novel synthesis of s-triazine derivatives because of their low cost and ease of availability. Methods: This scaffold has been extensively investigated mainly in the last decade only. Many products have been synthesized from different starting materials and these synthetic products possess anticancer potential against various cell lines. Results: Many of the 1,3,5-triazine analogs exhibited significant anticancer activity in various models and cell lines exhibiting mechanisms. Some of the analogs have also shown good pharmacokinetic parameters with less IC50 values. Conclusion: Various 1,3,5-triazine analogs have shown potent activities and may be regarded as the clinical candidates for future anticancer formulations. This review may be helpful to those researchers seeking required information with regard to the drug design and medicinal properties of 1,3,5-triazine derivatives for selected targets. This review may also offer help to find and improve the clinically viable anticancer molecules.

Keywords:

s-Triazine, anticancer, epidermal growth factor receptor, cytotoxic, vascular endothelial growth factor.

Affiliation:

Devsthali Vidyapeeth College of Pharmacy, Lalpur, Rudrapur (U.S. Nagar)-263148, Devsthali Vidyapeeth College of Pharmacy, Lalpur, Rudrapur (U.S. Nagar)-263148, Oriental College of Pharmacy, College of Pharmacy, Kumaun University, Bhimtal, Nainital-263136, Uttarakhand, Department of Pharmacy



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