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Computational Modeling of Dielectrophoretic Microfluidic Channel for Simultaneous Separation of Red Blood Cells and Platelets

[ Vol. 15 , Issue. 3 ]

Author(s):

S. Praveenkumar*, S. Nath Srigitha, Ram G. Dinesh and R. Ramesh   Pages 243 - 251 ( 9 )

Abstract:


Background: In this paper, the design and computational modeling of microfluidic channel capable of separating platelets and Red Blood Cell (RBC) from the other blood cells are proposed.

Materials and Methods: Separation based on their sizes is made possible by utilizing negative dielectrophoretic (n-DEP) force in fusion with drag force. An array of 38º angled electrode separated by 70 μm distance is designed within the microchannel and analyzed for non-uniform electric field distribution.

Results and Conclusion: The molecule movement within the microchannel under induced electric field is simulated to demonstrate the separation using the particle trajectories module. A numerical study is performed for the calculation of Clausius Mossotti (CM) factor, n-DEP force and drag force.

Keywords:

Microfluidics, biomolecule separation, dielectrophoresis, computational modeling, RBC, platelets.

Affiliation:

Department of Electronics and Communication Engineering, Saveetha Engineering College, Chennai, Tamilnadu, Department of Electronics and Communication Engineering, Saveetha Engineering College, Chennai, Tamilnadu, Department of Electronics and Communication Engineering, Saveetha Engineering College, Chennai, Tamilnadu, Department of Electronics and Communication Engineering, Saveetha Engineering College, Chennai, Tamilnadu

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